[Sci-all-l] ScienceDirect Top 25 Downloads

Thu Mar 8 09:56:45 EST 2007

nearly 11 million users, and 36 articles downloaded per second on an 
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I find it interesting that all but 2 seem molecular biology related.  Flora
<http://elsevier.dmdelivery.com/x/c.php/S7Y1_p9ra.G.yNbQzNTM4H_GbUZJSYGVvn55eblecXJmal5yakpmUWpyiV5yfu7.FFus4gA035>

  Visit the 
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Hottest Articles webpage to select another subject area or use the 
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Read more about 
<http://elsevier.dmdelivery.com/x/c.php/JctNCoAgEAbQq3QCraCIYPbdImL8SiF.0Im6vQXt3uYx9dXTVDN14zC21ZIVSbPWLuxRFXYIDOMyWBRHr6_CvFqc6Ze4VLTE1A9fMHhUseLPamiJd3MgIG8C8wIf56>how 
the TOP25 is generated and what it reflects.
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         TOP25 Hottest Articles - downloaded during October, November 
and December, 2006
Overall

1. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406014000&md5=9102493b2aedfd680d6c1e860efc56c3>Molecular 
Anatomy of a Trafficking Organelle * Article
Cell, Volume 127, Issue 4, 1 November 2006, Pages 831-846
Takamori, S.; Holt, M.; Stenius, K.; Lemke, E.A.; Gronborg, M.; 
Riedel, D.; Urlaub, H.; Schenck, S.; Brugger, B.; Ringler, P.; 
Muller, S.A.; Rammner, B.; Grater, F.; Hub, J.S.; De Groot, B.L.; 
Mieskes
2. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406012256&md5=218dba81bdbcc0210633d2c955c9c4eb>RETRACTED: 
Role of the Sigma Factor in Transcription Initiation in the Absence 
of Core RNA Polymerase * Article
Cell, Volume 127, Issue 2, 1 October 2006, Pages 317-327
Hsu, H.H.; Chung, K.M.; Chen, T.C.; Chang, B.Y.
3. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867400816839&md5=daa53fa060a4b8f3f538a10a7263296d>The 
Hallmarks of Cancer * Review article
Cell, Volume 100, Issue 1, 1 January 2000, Pages 57-70
Hanahan, D.; Weinberg, R.A.
4. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406009767&md5=68c0282aa422f48489956e7c505ab257>Induction 
of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast 
Cultures by Defined Factors * Article
Cell, Volume 126, Issue 4, 1 August 2006, Pages 663-676
Takahashi, K.; Yamanaka, S.
5. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406013444&md5=3dbfe93c8118f952b0887d6cb891aae4>Wnt/@b-Catenin 
Signaling in Development and Disease * Review article
Cell, Volume 127, Issue 3, 1 November 2006, Pages 469-480
Clevers, H.
6. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406014140&md5=0e3751f6b7d9925e74f5a4bb6deba54d>Cancer 
Metastasis: Building a Framework * Review article
Cell, Volume 127, Issue 4, 1 November 2006, Pages 679-695
Gupta, G.P.; Massague, J.
7. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406012748&md5=2c63359c4fa332d62839cea3b99a4f53>Global, 
In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling 
Networks * Short communication
Cell, Volume 127, Issue 3, 1 November 2006, Pages 635-648
Olsen, J.V.; Blagoev, B.; Gnad, F.; Macek, B.; Kumar, C.; Mortensen, 
P.; Mann, M.
8. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406012281&md5=c63bcbb3b36707e01670e85df3bcb206>Suppression 
of Reactive Oxygen Species and Neurodegeneration by the PGC-1 
Transcriptional Coactivators * Article
Cell, Volume 127, Issue 2, 1 October 2006, Pages 397-408
St-Pierre, J.; Drori, S.; Uldry, M.; Silvaggi, J.M.; Rhee, J.; Jager, 
S.; Handschin, C.; Zheng, K.; Lin, J.; Yang, W.; Simon, D.K.; Bachoo, 
R.; Spiegelman, B.M.
9. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=0040403995001486&md5=5aad7c3342ca3ee13e32b98dbc3fd7db>Conjugate 
Addition of gem-Borazirconocene Alkanes to Michael Acceptors * Article
Tetrahedron Letters, Volume 36, Issue 11, 1 March 1995, Pages 1805-1808
Pereira, S.; Srebnik, M.
10. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0140673606694208&md5=bf53443f01d74b64fd3660f5edddb443>Effect 
of rosiglitazone on the frequency of diabetes in patients with 
impaired glucose tolerance or impaired fasting glucose: a randomised 
controlled trial * Article
Lancet, The, Volume 368, Issue 9541, 1 September 2006, Pages 1096-1105
11. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406014280&md5=fae49167c32d14a2197c339d2dae6a5e>Resveratrol 
Improves Mitochondrial Function and Protects against Metabolic 
Disease by Activating SIRT1 and PGC-1 at a * Article
Cell, Volume 127, Issue 6, 1 December 2006, Pages 1109-1122
Lagouge, M.; Argmann, C.; Gerhart-Hines, Z.; Meziane, H.; Lerin, C.; 
Daussin, F.; Messadeq, N.; Milne, J.; Lambert, P.; Elliott, P.; Geny, 
B.; Laakso, M.; Puigserver, P.; Auwerx, J.
12. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406012773&md5=d0bfb1c7e8f89a30b9da145aeca78784>New 
Histone Incorporation Marks Sites of UV Repair in Human Cells * 
Article
Cell, Volume 127, Issue 3, 1 November 2006, Pages 481-493
Polo, S.E.; Roche, D.; Almouzni, G.
13. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406011056&md5=889591bf1b53384500cb5e7d90521f62>The 
Orphan Nuclear Receptor ROR at ct Directs the Differentiation Program of 
Proinflammatory IL-17^+ T Helper Cells * Article
Cell, Volume 126, Issue 6, 1 September 2006, Pages 1121-1133
Ivanov, I.I.; McKenzie, B.S.; Zhou, L.; Tadokoro, C.E.; Lepelley, A.; 
Lafaille, J.J.; Cua, D.J.; Littman, D.R.
14. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406012050&md5=f3b2832994a0fa00746e1bd0d41f8f60>Transcriptional 
Repression of PGC-1 at a by Mutant Huntingtin Leads to Mitochondrial 
Dysfunction and Neurodegeneration * Article
Cell, Volume 127, Issue 1, 1 October 2006, Pages 59-69
Cui, L.; Jeong, H.; Borovecki, F.; Parkhurst, C.N.; Tanese, N.; Krainc, D.
15. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S107476130600269X&md5=9833373f6f93bd32c032951fdf37a84c>Th17: 
An Effector CD4 T Cell Lineage with Regulatory T Cell Ties * Review 
article
Immunity, Volume 24, Issue 6, 1 June 2006, Pages 677-688
Weaver, C.T.; Harrington, L.E.; Mangan, P.R.; Gavrieli, M.; Murphy, K.M.
16. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406013432&md5=780ac68f95635459541eaed74862d0fe>The 
C Terminus of the L-Type Voltage-Gated Calcium Channel Ca"V1.2 
Encodes a Transcription Factor * Article
Cell, Volume 127, Issue 3, 1 November 2006, Pages 591-606
Gomez-Ospina, N.; Tsuruta, F.; Barreto-Chang, O.; Hu, L.; Dolmetsch, R.
17. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0896627306007227&md5=4b1034988d49db68610fc7492a450280>Neurobiology 
of Schizophrenia * Review article
Neuron, Volume 52, Issue 1, 1 October 2006, Pages 139-153
Ross, C.A.; Margolis, R.L.; Reading, S.A.J.; Pletnikov, M.; Coyle, J.T.
18. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0140673606691137&md5=121055d0b1aa44a2ed6de03963a8de56>Alzheimer's 
disease * Review article
Lancet, The, Volume 368, Issue 9533, 1 July 2006, Pages 387-403
Blennow, K.; de Leon, M.J.; Zetterberg, H.
19. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406011470&md5=4942913f5c762e2710c859e36b9e0d97>SIN1/MIP1 
Maintains rictor-mTOR Complex Integrity and Regulates Akt 
Phosphorylation and Substrate Specificity * Article
Cell, Volume 127, Issue 1, 1 October 2006, Pages 125-137
Jacinto, E.; Facchinetti, V.; Liu, D.; Soto, N.; Wei, S.; Jung, S.Y.; 
Huang, Q.; Qin, J.; Su, B.
20. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0304885306007542&md5=3dd943fa72e2a59aba6895c74547c676>Magnetic 
field heating study of Fe-doped Au nanoparticles * Article
Journal of Magnetism and Magnetic Materials, Volume 309, Issue 1, 1 
February 2007, Pages 15-19
Wijaya, A.; Brown, K.A.; Alper, J.D.; Hamad-Schifferli, K.
21. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406012840&md5=a9fa0596fe9d421dc68940c3e5e35a02>The 
Regulation of INK4/ARF in Cancer and Aging * Review article
Cell, Volume 127, Issue 2, 1 October 2006, Pages 265-275
Kim, W.Y.; Sharpless, N.E.
22. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406011627&md5=781296ac05c3cbe8a21db4fbb09ecfea>Tcf3 
Governs Stem Cell Features and Represses Cell Fate Determination in 
Skin * Article
Cell, Volume 127, Issue 1, 1 October 2006, Pages 171-183
Nguyen, H.; Rendl, M.; Fuchs, E.
23. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0140673606697055&md5=610608ede2d04f53603d40b1382ec3a2>The 
incretin system: glucagon-like peptide-1 receptor agonists and 
dipeptidyl peptidase-4 inhibitors in type 2 diabetes * Review article
Lancet, The, Volume 368, Issue 9548, 1 November 2006, Pages 1696-1705
Drucker, D.J.; Nauck, M.A.
24. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S1534580706004023&md5=f0370029825027cebf0a3c71dd793a1e>The 
Diverse Functions of MicroRNAs in Animal Development and Disease * 
Review article
Developmental Cell, Volume 11, Issue 4, 1 October 2006, Pages 441-450
Kloosterman, W.P.; Plasterk, R.H.A.
25. 
	<http://www.sciencedirect.com/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SDTOPTWOFIVE&_version=1&_piikey=S0092867406012074&md5=295918d7ecad019fb4908d53e66d8431>Presenilin-Dependent 
ErbB4 Nuclear Signaling Regulates the Timing of Astrogenesis in the 
Developing Brain * Article
Cell, Volume 127, Issue 1, 1 October 2006, Pages 185-197
Sardi, S.P.; Murtie, J.; Koirala, S.; Patten, B.A.; Corfas, G.

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